One of the biggest problems for learners of a foreign language is when their first language has a superordinate word and the foreign language has two (or more) hyponyms. For example, even after speaking Chinese for 40 years, I still get caught out by the distinction between 穿 chuān and 戴 dài, both of which are 'wear' in English. In Chinese, you use 穿 for clothes and 戴 for peripheral things like hats or seat-belts; but in English we say 'wear a shirt', 'wear socks', 'wear a hat' and 'wear a seatbelt'.
In speaking Malay, the same problems might occur for padi, beras and nasi, all of which are 'rice' in English. However, I find it easier to to keep those apart, as they are nouns, and it is easier to remember that padi is growing in the fields, beras is for sale in a shop, and nasi is already cooked.
What about the other way round? Chinese speakers of English often confuse 'he' and 'she' in English, because although they are differentiated in writing as 他 and 她, both are pronounced the same: tā.
For Malay learners of English, I would expect that the distinction between 'pain' and 'sickness' would be problematic, as both are sakit in Malay.